diff --git a/src/docx/__init__.py b/src/docx/__init__.py
index fd06c84d2..e422adddc 100644
--- a/src/docx/__init__.py
+++ b/src/docx/__init__.py
@@ -44,6 +44,7 @@ def part_class_selector(content_type: str, reltype: str) -> Type[Part] | None:
 PartFactory.part_type_for[CT.OPC_CORE_PROPERTIES] = CorePropertiesPart
 PartFactory.part_type_for[CT.WML_COMMENTS] = CommentsPart
 PartFactory.part_type_for[CT.WML_DOCUMENT_MAIN] = DocumentPart
+PartFactory.part_type_for[CT.WML_DOCUMENT_MAIN_WITH_MACROS] = DocumentPart
 PartFactory.part_type_for[CT.WML_FOOTER] = FooterPart
 PartFactory.part_type_for[CT.WML_HEADER] = HeaderPart
 PartFactory.part_type_for[CT.WML_NUMBERING] = NumberingPart
diff --git a/src/docx/api.py b/src/docx/api.py
index aea876458..fc355e0bf 100644
--- a/src/docx/api.py
+++ b/src/docx/api.py
@@ -25,7 +25,7 @@ def Document(docx: str | IO[bytes] | None = None) -> DocumentObject:
     """
     docx = _default_docx_path() if docx is None else docx
     document_part = cast("DocumentPart", Package.open(docx).main_document_part)
-    if document_part.content_type != CT.WML_DOCUMENT_MAIN:
+    if document_part.content_type not in (CT.WML_DOCUMENT_MAIN, CT.WML_DOCUMENT_MAIN_WITH_MACROS):
         tmpl = "file '%s' is not a Word file, content type is '%s'"
         raise ValueError(tmpl % (docx, document_part.content_type))
     return document_part.document
diff --git a/src/docx/opc/constants.py b/src/docx/opc/constants.py
index a3d0e0812..c2a6a5079 100644
--- a/src/docx/opc/constants.py
+++ b/src/docx/opc/constants.py
@@ -135,6 +135,9 @@ class CONTENT_TYPE:
     WML_DOCUMENT_MAIN = (
         "application/vnd.openxmlformats-officedocument.wordprocessingml.document.main+xml"
     )
+    WML_DOCUMENT_MAIN_WITH_MACROS = (
+        "application/vnd.ms-word.document.macroEnabled.main+xml"
+    )
     WML_ENDNOTES = "application/vnd.openxmlformats-officedocument.wordprocessingml.endnotes+xml"
     WML_FONT_TABLE = "application/vnd.openxmlformats-officedocument.wordprocessingml.fontTable+xml"
     WML_FOOTER = "application/vnd.openxmlformats-officedocument.wordprocessingml.footer+xml"