diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 48b6e7202b..796bc3b330 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -14,8 +14,6 @@ jobs:
     strategy:
       matrix:
         python-version:
-        - '3.6'
-        - '3.7'
         - '3.8'
         - '3.9'
         - '3.10'
@@ -36,18 +34,9 @@ jobs:
     - name: Install dependencies
       run: python -m pip install --upgrade codecov tox
 
-    - name: Install tox-py
-      if: ${{ matrix.python-version == '3.6' }}
-      run: python -m pip install --upgrade tox-py
-
     - name: Run tox targets for ${{ matrix.python-version }}
-      if: ${{ matrix.python-version != '3.6' }}
       run: tox run -f py$(echo ${{ matrix.python-version }} | tr -d .)
 
-    - name: Run tox targets for ${{ matrix.python-version }}
-      if: ${{ matrix.python-version == '3.6' }}
-      run: tox --py current
-
     - name: Run extra tox targets
       if: ${{ matrix.python-version == '3.9' }}
       run: |
diff --git a/README.md b/README.md
index c2975a418f..b55c525014 100644
--- a/README.md
+++ b/README.md
@@ -54,7 +54,7 @@ There is a live example API for testing purposes, [available here][sandbox].
 
 # Requirements
 
-* Python 3.6+
+* Python 3.8+
 * Django 4.2, 4.1, 4.0, 3.2, 3.1, 3.0
 
 We **highly recommend** and only officially support the latest patch release of
diff --git a/docs/index.md b/docs/index.md
index 81a5563133..406596367a 100644
--- a/docs/index.md
+++ b/docs/index.md
@@ -85,7 +85,7 @@ continued development by **[signing up for a paid plan][funding]**.
 
 REST framework requires the following:
 
-* Python (3.6, 3.7, 3.8, 3.9, 3.10, 3.11)
+* Python (3.8, 3.9, 3.10, 3.11)
 * Django (3.0, 3.1, 3.2, 4.0, 4.1, 4.2)
 
 We **highly recommend** and only officially support the latest patch release of
diff --git a/setup.py b/setup.py
index 6afd5e05e7..a1d74529f2 100755
--- a/setup.py
+++ b/setup.py
@@ -8,7 +8,7 @@
 from setuptools import find_packages, setup
 
 CURRENT_PYTHON = sys.version_info[:2]
-REQUIRED_PYTHON = (3, 6)
+REQUIRED_PYTHON = (3, 8)
 
 # This check and everything above must remain compatible with Python 2.7.
 if CURRENT_PYTHON < REQUIRED_PYTHON:
@@ -84,7 +84,7 @@ def get_version(package):
     packages=find_packages(exclude=['tests*']),
     include_package_data=True,
     install_requires=["django>=3.0", 'backports.zoneinfo;python_version<"3.9"'],
-    python_requires=">=3.6",
+    python_requires=">=3.8",
     zip_safe=False,
     classifiers=[
         'Development Status :: 5 - Production/Stable',
@@ -101,8 +101,6 @@ def get_version(package):
         'Operating System :: OS Independent',
         'Programming Language :: Python',
         'Programming Language :: Python :: 3',
-        'Programming Language :: Python :: 3.6',
-        'Programming Language :: Python :: 3.7',
         'Programming Language :: Python :: 3.8',
         'Programming Language :: Python :: 3.9',
         'Programming Language :: Python :: 3.10',
diff --git a/tests/test_fields.py b/tests/test_fields.py
index 7006d473c2..54d2d284a3 100644
--- a/tests/test_fields.py
+++ b/tests/test_fields.py
@@ -640,10 +640,6 @@ def test_parent_binding(self):
 
 
 class TestTyping(TestCase):
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_field_is_subscriptable(self):
         assert serializers.Field is serializers.Field["foo"]
 
diff --git a/tests/test_generics.py b/tests/test_generics.py
index 9990389c94..8748e8f170 100644
--- a/tests/test_generics.py
+++ b/tests/test_generics.py
@@ -1,5 +1,3 @@
-import sys
-
 import pytest
 from django.db import models
 from django.http import Http404
@@ -703,23 +701,11 @@ def list(self, request):
 
 
 class TestTyping(TestCase):
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_genericview_is_subscriptable(self):
         assert generics.GenericAPIView is generics.GenericAPIView["foo"]
 
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_listview_is_subscriptable(self):
         assert generics.ListAPIView is generics.ListAPIView["foo"]
 
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_instanceview_is_subscriptable(self):
         assert generics.RetrieveAPIView is generics.RetrieveAPIView["foo"]
diff --git a/tests/test_model_serializer.py b/tests/test_model_serializer.py
index 20d0319fcb..b48c9f9036 100644
--- a/tests/test_model_serializer.py
+++ b/tests/test_model_serializer.py
@@ -8,7 +8,6 @@
 import datetime
 import decimal
 import json  # noqa
-import sys
 import tempfile
 
 import django
@@ -398,10 +397,6 @@ class Meta:
                 fields = '__all__'
 
         expected = dedent("""
-            TestSerializer():
-                id = IntegerField(label='ID', read_only=True)
-                duration_field = DurationField(max_value=datetime.timedelta(3), min_value=datetime.timedelta(1))
-        """) if sys.version_info < (3, 7) else dedent("""
             TestSerializer():
                 id = IntegerField(label='ID', read_only=True)
                 duration_field = DurationField(max_value=datetime.timedelta(days=3), min_value=datetime.timedelta(days=1))
diff --git a/tests/test_request.py b/tests/test_request.py
index e37aa7dda1..7fd876622c 100644
--- a/tests/test_request.py
+++ b/tests/test_request.py
@@ -3,7 +3,6 @@
 """
 import copy
 import os.path
-import sys
 import tempfile
 
 import pytest
@@ -356,9 +355,5 @@ def test_deepcopy_works(self):
 
 
 class TestTyping(TestCase):
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_request_is_subscriptable(self):
         assert Request is Request["foo"]
diff --git a/tests/test_response.py b/tests/test_response.py
index cab19a1eb8..a5b8e8398b 100644
--- a/tests/test_response.py
+++ b/tests/test_response.py
@@ -1,6 +1,3 @@
-import sys
-
-import pytest
 from django.test import TestCase, override_settings
 from django.urls import include, path, re_path
 
@@ -289,9 +286,5 @@ def test_form_has_label_and_help_text(self):
 
 
 class TestTyping(TestCase):
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_response_is_subscriptable(self):
         assert Response is Response["foo"]
diff --git a/tests/test_serializer.py b/tests/test_serializer.py
index 39d9238ef9..92bf7fb458 100644
--- a/tests/test_serializer.py
+++ b/tests/test_serializer.py
@@ -206,10 +206,6 @@ class ExampleSerializer(serializers.Serializer):
                 exceptions.ErrorDetail(string='Raised error', code='invalid')
             ]}
 
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_serializer_is_subscriptable(self):
         assert serializers.Serializer is serializers.Serializer["foo"]
 
diff --git a/tests/test_serializer_lists.py b/tests/test_serializer_lists.py
index 4070de7a51..42ebf4771e 100644
--- a/tests/test_serializer_lists.py
+++ b/tests/test_serializer_lists.py
@@ -1,5 +1,3 @@
-import sys
-
 import pytest
 from django.http import QueryDict
 from django.utils.datastructures import MultiValueDict
@@ -60,10 +58,6 @@ def test_validate_html_input(self):
         assert serializer.is_valid()
         assert serializer.validated_data == expected_output
 
-    @pytest.mark.skipif(
-        sys.version_info < (3, 7),
-        reason="subscriptable classes requires Python 3.7 or higher",
-    )
     def test_list_serializer_is_subscriptable(self):
         assert serializers.ListSerializer is serializers.ListSerializer["foo"]
 
diff --git a/tox.ini b/tox.ini
index 2b8733d7df..15309ed144 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,8 +1,8 @@
 [tox]
 envlist =
-       {py36,py37,py38,py39}-django30
-       {py36,py37,py38,py39}-django31
-       {py36,py37,py38,py39,py310}-django32
+       {py38,py39}-django30
+       {py38,py39}-django31
+       {py38,py39,py310}-django32
        {py38,py39,py310}-{django40,django41,django42,djangomain}
        {py311}-{django41,django42,djangomain}
        base